Associate Professor of the Department of Nervous Diseases presented a plenary report at an International Symposium at the University of Cape Town

On November 14-18, 2022, the XVII International Symposium on Intracranial Pressure and Brain Monitoring was held at the University of Cape Town (the Republic of South Africa). More than 200 participants from all over the world presented the results of recent experimental and multicenter clinical research into intracranial hypertension and cerebral blood flow. A representative of PRMU – Alex Trofimov, Associate Professor of the Department of Nervous Diseases – was on the Russian delegation.

The PRMU scientist made a plenary report on Intracranial Dynamics Biomarkers at Traumatic Cerebral Vasospasm. The work presented the results of many years of research in collaboration with the leading scientific centers of the world with regard to neuromonitoring for TBI. The report sparked much interest and was followed by a discussion among the conference participants, as it touched upon the pressing issue of personalized medicine – bio markering in traumatic brain injury.

Members of the Department of Nervous Diseases of PRMU in cooperation with the teams of the departments of Radiation Diagnostics and Combined Trauma of the Regional Clinical Hospital named after N.A. Semashko and Nizhny Novgorod State Technical University named after R.E. Alekseev gave a number of poster presentations at the conference based on the materials of large-scale international cooperation. Among them are two reports on Posttraumatic ischemia and brain water content: preliminary CT perfusion study and Arteriovenous Coupling at Moderate-to-Severe Traumatic Brain Injury: A Multiphase CT Perfusion Study. Both the research papers used cutting-edge methods to study changes in the brain caused by its injury and were widely discussed among experts.

International collaboration between the teams of PRMU (Assoc. Prof. Alex O. Trofimov) and Department of Neurosurgery, Lovelace Health System (USA) (Prof. Edwin M Nemoto and Prof. Denis Bragin), presented the results of research in basic science: Drag Reducing Polymer (DRP) in the Treatment of Cerebral Ischemia and Microvascular Shunts in Severe Traumatic Brain Injury (sTBI). It was demonstrated that cerebrovascular drag was non-linearly dependent on ICP, which opened new doors for compensating critical intracranial hypertension in brain injuries. It was proved that cerebral blood flow could be enhanced in patients with intracranial hypertension through the use of nanopolymers that reduce blood viscosity and improve its fluidity.

Within the framework of the conference, satellite symposia of international societies – ICM+ and Global Neurosurgery – were held outlining the frontiers of recent research into fundamental neuroscience and highly evidence-based multicenter research in neurosurgery.